Big dick for a small white girl Monsters of Cock. One possible reason why studies did not detect an increase in glutamate levels after administration of rewarding doses of cocaine could be due to slow temporal resolution of the in vivo microdialysis technique. Introduction Rewards increase motivation to perform or repeat tasks and can be broadly classified as natural and drug rewards Schultz, Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. Intriguingly, increase in VTA glutamate levels was also observed in cocaine-experienced animal after an intraperitoneal injection of cocaine methiodide, which does not cross the blood brain barrier Wise et al.
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Finally, mice lacking the gene for the synaptic scaffolding protein Homer 2b showed reduced alcohol preference and alcohol-induced CPP, suggesting that Homer 2b protein is involved in the reinforcing effects of alcohol Szumlinski et al. Interestingly, chronic alcohol consumption in male alcohol-preferring P rats resulted in decreased expression of xCT in the NAcc, suggesting that manipulation of the exchanger in the NAcc may alter the rewarding effects of alcohol Alhaddad et al. Rats with low sensitivity to the behavioral effects of alcohol showed an increase in NAcc glutamate levels, while rats with high sensitivity to alcohol showed a decrease in NAcc glutamate levels but also see Quertemont et al. Regulation of glutamate receptor subunit availability by microRNAs. Intriguingly, several animal studies have shown that NMDA receptors have rewarding effects of their own Carlezon and Wise,
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Differential establishment and maintenance of oral ethanol reinforced behavior in Lewis and Fischer inbred rat strains. Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons. The effects of the mGluR5 receptor antagonist 6-methyl phenylethynyl -pyridine MPEP on the stimulation of dopamine release evoked by nicotine in the rat brain. Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine. Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions. Viral-mediated knockdown of mGluR7 in the nucleus accumbens mediates excessive alcohol drinking and increased ethanol-elicited conditioned place preference in rats.
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